POB or Pob may refer to:

• Parti Ouvrier Belge (Belgian Workers Party), forerunner of the Socialist Party (Belgium)
• Place of birth
• Pob, central character of Pob's Programme, a British children's TV programme (ran 1985–1990)
• Patrick O'Brian, novelist and author
• Poblacion or Pop, a term for the central business district of a Philippine city
• Pope Field (IATA: POB), Fayetteville, North Carolina, U.S., a military air base
• Positive Organizational Behavior, an application of psychology
• Professional Oversight Board, independent oversight of professional organizations in the United Kingdom
• Personnel on board, an abbreviation in oil and gas exploration and production and in shipbuilding
• "Pilot on board", by which the time of the pilot's boarding the ship is understood
• Person overboard, a gender-neutral equivalent of the expression "Man overboard"
• "Pob", an episode of Folklore